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An ultra-sensitive and ratiometric fluorescent probe based on the DTBET process for Hg2+ detection and imaging applications

Abstract

In this article, we present an ultra-sensitive and ratiometric fluorescent probe (TR-Hg) for Hg2+ detection based on the mechanism of aggregation induced emission (AIE) and dark through-bond energy transfer (DTBET). The probe is constructed using tetraphenylethene as the dark donor and rhodamine B thiolactone as the acceptor. Exploiting the advantage of DTBET, which eliminates emission leakage from dark donors and provides a nearly 100% energy transfer efficiency, TR-Hg exhibits more than a 30,000-fold fluorescence ratio enhancement after reacting with Hg2+. The TR-Hg demostrates: (i) a detection limit of 43 pM, which is the lowest among the reported ratiometric Hg2+ probes , (ii) excellent selectivity, fast response (10 s) and a wide pH application range, (iii) strong applicability to be towards paper-based colorimetric assay, where readout can be performed by the naked eye, and (iv) fluorescent imaging of Hg2+ in onion epidermal tissues, indicating potential use in living organisms.

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Publication details

The article was received on 04 Nov 2018, accepted on 05 Dec 2018 and first published on 06 Dec 2018


Article type: Paper
DOI: 10.1039/C8AN02126K
Citation: Analyst, 2018, Accepted Manuscript
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    An ultra-sensitive and ratiometric fluorescent probe based on the DTBET process for Hg2+ detection and imaging applications

    J. Yin, Q. Duan, G. Zheng, Y. Liu, J. Zhang, Y. Wang, H. Zhang, J. He, H. Sun and D. Ho, Analyst, 2018, Accepted Manuscript , DOI: 10.1039/C8AN02126K

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