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Novel dual response ratiometric fluorescence probe for determination of H2O2 and glucose via etching of silver nanoparticles

Abstract

Based on inner filter effect and charge transfer dual response mechanism, a dual response ratiometric fluorescent probe (D-RFP) with two reversible signal changes for sensing H2O2 and glucose was developed. The D-RFP was proposed by embedding glycine-derived carbon dots (CDs) (λem=400 nm) into silica nanoparticles and covalently linking CdTe quantum dots (QDs) (λem=600 nm) onto the surface of silica nanaoparticles. When mixed silver nanoparticles (Ag NPs) with D-RFP, the fluorescent intensity of CDs can be quenched by Ag NPs via inner filter effect. With the addition of H2O2 , Ag NPs were etched to silver ions, thus recovering the fluorescent of CDs. In the meanwhile, fluorescent of QDs was quenched by Ag+ via charge transfer. Under optimal condition, D-RFP displayed high sensitivity toward H2O2 with a detection limit of 0.28 μM. Based on the conversion of glucose into H2O2 , D-RFP can also be exploited for glucose sensing with a detection limit of 0.59 μM. The approach developed can be applied to monitor glucose levels in human serum samples with satisfactory results, and the health and diabetics can be distinguished by the naked eye. Moreover, this method provides a new idea for designing high-sensitivity D-RFP.

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Publication details

The article was received on 20 Oct 2018, accepted on 14 Nov 2018 and first published on 21 Nov 2018


Article type: Paper
DOI: 10.1039/C8AN02019A
Citation: Analyst, 2018, Accepted Manuscript
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    Novel dual response ratiometric fluorescence probe for determination of H2O2 and glucose via etching of silver nanoparticles

    H. Lu, C. Yu, S. Quan and S. Xu, Analyst, 2018, Accepted Manuscript , DOI: 10.1039/C8AN02019A

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