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A translational approach to assess the metabolomic impact of stabilized gold nanoparticles by NMR spectroscopy

Abstract

Gold nanoparticles have a high potential in the biomedical area, with a special emphasis in disease diagnosis and treatment. The application of these nanoparticles requires the presence of stabilizers to avoid their agglomeration. Nowadays, there is a lack of reliable methods for characterising the effect of stabilised nanoparticles on biological systems. To this end, in this study, we apply an experimental approach based on nuclear magnetic resonance spectroscopy to study the effect of gold nanoparticles, stabilised with cerium oxide or chitosan on a human cancer cell model. The results showed that both systems have a significant effect, even at non-toxic levels, on the cellular antioxidant system. However, although particles functionalised with chitosan exerted a strong effect on the aerobic respiration, nanoparticles stabilised with cerium oxide had a higher impact on the mechanisms associated with anaerobic energy production. Therefore, even though that both systems contained similar gold nanoparticles, the presence of different stabilizers strongly influenced their mode of action and potential applications in biomedicine.

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Publication details

The article was received on 21 Sep 2018, accepted on 25 Nov 2018 and first published on 26 Nov 2018


Article type: Paper
DOI: 10.1039/C8AN01827H
Citation: Analyst, 2018, Accepted Manuscript
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    A translational approach to assess the metabolomic impact of stabilized gold nanoparticles by NMR spectroscopy

    J. R. Herance, H. Garcia, P. C. Gutierrez, S. Navalon, A. Pineda-Lucena and M. Palomino-Schätzlein, Analyst, 2018, Accepted Manuscript , DOI: 10.1039/C8AN01827H

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