Issue 20, 2018

In vivo detection of drug-induced apoptosis in tumors using Raman spectroscopy

Abstract

We describe a label-free approach based on Raman spectroscopy, to study drug-induced apoptosis in vivo. Spectral-shifts at wavenumbers associated with DNA, proteins, lipids, and collagen have been identified on breast and melanoma tumor tissues. These findings may enable a new analytical method for rapid readout of drug-therapy with miniaturized probes.

Graphical abstract: In vivo detection of drug-induced apoptosis in tumors using Raman spectroscopy

Supplementary files

Article information

Article type
Communication
Submitted
16 May 2018
Accepted
21 Jul 2018
First published
30 Jul 2018
This article is Open Access
Creative Commons BY-NC license

Analyst, 2018,143, 4836-4839

In vivo detection of drug-induced apoptosis in tumors using Raman spectroscopy

O. Jonas, J. W. Kang, S. P. Singh, A. Lammers, F. T. Nguyen, R. R. Dasari, P. T. C. So, R. Langer and M. J. Cima, Analyst, 2018, 143, 4836 DOI: 10.1039/C8AN00913A

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