Jump to main content
Jump to site search

Issue 11, 2018
Previous Article Next Article

The growing role of structural mass spectrometry in the discovery and development of therapeutic antibodies

Author affiliations

Abstract

The comprehensive structural characterization of therapeutic antibodies is of critical importance for the successful discovery and development of such biopharmaceuticals, yet poses many challenges to modern measurement science. Mass spectrometry has evolved into a rapid and sensitive tool for assessing the structures, stabilities, and dynamics of such proteins. Here, we review the current state-of-the-art mass spectrometry technologies focusing on the characterization of antibody-based therapeutics. We conclude by discussing the future of structural mass spectrometry, and its role in enabling the biopharmaceutical pipeline.

Graphical abstract: The growing role of structural mass spectrometry in the discovery and development of therapeutic antibodies

Back to tab navigation

Publication details

The article was received on 14 Feb 2018, accepted on 27 Apr 2018 and first published on 30 Apr 2018


Article type: Critical Review
DOI: 10.1039/C8AN00295A
Citation: Analyst, 2018,143, 2459-2468
  •   Request permissions

    The growing role of structural mass spectrometry in the discovery and development of therapeutic antibodies

    Y. Tian and B. T. Ruotolo, Analyst, 2018, 143, 2459
    DOI: 10.1039/C8AN00295A

Search articles by author

Spotlight

Advertisements