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Issue 9, 2018
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A narrow open tubular column for high efficiency liquid chromatographic separation

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Abstract

We report a great feature of open tubular liquid chromatography when it is run using an extremely narrow (e.g., 2 μm inner diameter) open tubular column: more than 10 million plates per meter can be achieved in less than 10 min and under an elution pressure of ca. 20 bar. The column is coated with octadecylsilane and both isocratic and gradient separations are performed. We reveal a focusing effect that may be used to interpret the efficiency enhancement. We also demonstrate the feasibility of using this technique for separating complex peptide samples. This high-resolution and fast separation technique is promising and can lead to a powerful tool for trace sample analysis.

Graphical abstract: A narrow open tubular column for high efficiency liquid chromatographic separation

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Supplementary files

Article information


Submitted
21 Dec 2017
Accepted
15 Mar 2018
First published
15 Mar 2018

Analyst, 2018,143, 2008-2011
Article type
Communication
Author version available

A narrow open tubular column for high efficiency liquid chromatographic separation

H. Chen, Y. Yang, Z. Qiao, P. Xiang, J. Ren, Y. Meng, K. Zhang, J. Juan Lu and S. Liu, Analyst, 2018, 143, 2008
DOI: 10.1039/C7AN02065A

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