Highly selective tridentate fluorescent probes for visualizing intracellular Mg2+ dynamics without interference from Ca2+ fluctuation

Yusuke Matsui; Kalyan K. Sadhu; Shin Mizukami; Kazuya Kikuchi

doi:10.1039/C7CC06141B

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Highly selective tridentate fluorescent probes for visualizing intracellular Mg²⁺ dynamics without interference from Ca²⁺ fluctuation†

Yusuke Matsui,

^a Kalyan K. Sadhu,‡^a Shin Mizukami

*^b and Kazuya Kikuchi

*^ac

Author affiliations

* Corresponding authors

^a Department of Material and Life Science, Graduate School of Engineering, Osaka University, Suita, Osaka 565-0871, Japan
E-mail: kkikuchi@mls.eng.osaka-u.ac.jp

^b Institute of Multidisciplinary Research for Advanced Materials, Tohoku University, Sendai, Miyagi 980-8577, Japan
E-mail: shin.mizukami@m.tohoku.ac.jp

^c WPI-Immunology Frontier Research Center, Osaka University, Suita, Osaka 565-0871, Japan

Abstract

We developed highly selective fluorescent Mg²⁺ probes based on a novel tridentate Mg²⁺-selective chelator. The superior selectivity for Mg²⁺ over Ca²⁺ enabled the detection of intracellular Mg²⁺ concentration changes without any response to Ca²⁺ influx. The new probes are potential keys to elucidating intracellular Mg²⁺ dynamics under conditions of extremely sharp Ca²⁺ fluctuation.

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Article information

DOI: https://doi.org/10.1039/C7CC06141B
Article type: Communication
Submitted: 06 Aug 2017
Accepted: 30 Aug 2017
First published: 30 Aug 2017

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Chem. Commun., 2017,53, 10644-10647

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Highly selective tridentate fluorescent probes for visualizing intracellular Mg²⁺ dynamics without interference from Ca²⁺ fluctuation

Y. Matsui, K. K. Sadhu, S. Mizukami and K. Kikuchi, Chem. Commun., 2017, 53, 10644 DOI: 10.1039/C7CC06141B

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