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Issue 1, 2017
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A DEHP plasticizer alters synaptic proteins via peroxidation

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Di-(2-ethylhexyl) phthalate (DEHP) is a widely used commercial plasticizer. DEHP exposure has a negative impact on brain development and cognition, but the mechanisms responsible for DEHP-induced neurotoxicity are not well understood. Here we showed that DEHP exposure increased maleic dialdehyde and reactive oxygen species contents and decreased endogenous superoxide dismutase activity in a mouse neuroblastoma cell line (N2a cell line). DEHP exposure not only induced reduction of neurite outgrowth, but also led to microtubule-associated protein tau hyperphosphorylation and dissociation from microtubules. Furthermore, DEHP exposure decreased the levels of synapsin-1 and postsynaptic density protein 95 (PSD95), which play critical roles in synaptic function. Antioxidant vitamin E pretreatment prevented DEHP-induced abnormalities in the cells. These results indicate that DEHP exposure could induce abnormal action of proteins including tau, synapsin-1 and PSD95, which play critical roles in the synaptic structure and function, and that these alterations might be mediated by peroxidative damage.

Graphical abstract: A DEHP plasticizer alters synaptic proteins via peroxidation

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Publication details

The article was received on 18 Sep 2016, accepted on 01 Nov 2016 and first published on 02 Nov 2016

Article type: Paper
DOI: 10.1039/C6TX00361C
Toxicol. Res., 2017,6, 89-97

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    A DEHP plasticizer alters synaptic proteins via peroxidation

    S. Wang, P. Zhang, R. Liu, Y. Li, C. Liu and X. Liao, Toxicol. Res., 2017, 6, 89
    DOI: 10.1039/C6TX00361C

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