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Issue 2, 2017
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Heteropoly blue doped polymer nanoparticles: an efficient theranostic agent for targeted photoacoustic imaging and near-infrared photothermal therapy in vivo

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Abstract

With the development of personalized medicine, the research of theranostic agents with good biocompatibility, stability, and targeting properties remains meaningful. Herein, we report a two-step process to construct heteropoly blue (HPB) doped polymer nanoparticles (HPB/P4VP-b-PEO NPs) with efficient near-infrared (NIR) light absorption and photothermal conversion efficiency of ∼23% to simultaneously perform photoacoustic imaging and photothermal therapy in vivo. After intravenous injection into the 4T1 xenograft model, in vivo photoacoustic imaging confirmed the targeted property of HPB/P4VP-b-PEO NPs due to the enhanced EPR effect. The photoacoustic signal in the tumor at 24 h p.i. was more than ∼10 times that of the pre-injection group. By virtue of their EPR effect, HPB/P4VP-b-PEO NPs achieved a good photothermal therapeutic efficacy in vivo.

Graphical abstract: Heteropoly blue doped polymer nanoparticles: an efficient theranostic agent for targeted photoacoustic imaging and near-infrared photothermal therapy in vivo

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Publication details

The article was received on 11 Oct 2016, accepted on 21 Nov 2016 and first published on 23 Nov 2016


Article type: Paper
DOI: 10.1039/C6TB02652D
Citation: J. Mater. Chem. B, 2017,5, 382-387
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    Heteropoly blue doped polymer nanoparticles: an efficient theranostic agent for targeted photoacoustic imaging and near-infrared photothermal therapy in vivo

    Y. Yan, Q. Yang, J. Wang, H. Jin, J. Wang, H. Yang, Z. Zhou, Q. Tian and S. Yang, J. Mater. Chem. B, 2017, 5, 382
    DOI: 10.1039/C6TB02652D

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