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Issue 10, 2017
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Protein diffusion in a bicontinuous microemulsion: inducing sub-diffusion by tuning the water domain size

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Abstract

We study the diffusion of an enhanced green fluorescent protein (GFP+) in bicontinuous sugar-surfactant based microemulsions. The size of the water domains in such systems is controlled by changes of the oil-to-water ratio. Hence, microemulsions allow to produce confinement effects in a controlled way. At high water content the protein is found to exhibit Fickian diffusion. Decreasing the water domain size leads to a slowing down of the protein diffusion and sub-diffusive behavior is obtained on the scale observed by fluorescence correlation spectroscopy. Further decrease of the water domain size finally nearly fixes the GFP+ in these domains and forces it to increasingly follow the breathing mode of the microemulsion matrix.

Graphical abstract: Protein diffusion in a bicontinuous microemulsion: inducing sub-diffusion by tuning the water domain size

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Publication details

The article was received on 15 Sep 2016, accepted on 09 Feb 2017 and first published on 09 Feb 2017


Article type: Paper
DOI: 10.1039/C6SM02107G
Soft Matter, 2017,13, 1998-2003

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    Protein diffusion in a bicontinuous microemulsion: inducing sub-diffusion by tuning the water domain size

    R. Neubauer, S. Höhn, M. Dulle, A. Lapp, C. Schulreich and T. Hellweg, Soft Matter, 2017, 13, 1998
    DOI: 10.1039/C6SM02107G

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