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Issue 5, 2017
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Copper-catalyzed direct alkylation of heteroarenes

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Abstract

An efficient and broadly applicable process is reported for the direct alkylation of C–H bonds in heteroarenes, privileged scaffolds in many areas of science. This reaction is based on the copper-catalyzed addition of alkyl radicals generated from activated secondary and tertiary alkyl bromides to a wide range of arenes, including furans, thiophenes, pyrroles, and their benzo-fused derivatives, as well as coumarins and quinolinones.

Graphical abstract: Copper-catalyzed direct alkylation of heteroarenes

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Article information


Submitted
22 Dec 2016
Accepted
17 Mar 2017
First published
20 Mar 2017

This article is Open Access
All publication charges for this article have been paid for by the Royal Society of Chemistry

Chem. Sci., 2017,8, 3465-3470
Article type
Edge Article

Copper-catalyzed direct alkylation of heteroarenes

C. Theunissen, J. Wang and G. Evano, Chem. Sci., 2017, 8, 3465
DOI: 10.1039/C6SC05622A

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