Issue 2, 2017

Palladium(0)-catalyzed asymmetric C(sp3)–H arylation using a chiral binol-derived phosphate and an achiral ligand

Abstract

The first efficient palladium(0)-catalyzed enantioselective C(sp3)–H activation reaction using a catalytic chiral base and an achiral phosphine ligand is reported. Fine-tuning the binol-derived phosphoric acid pre-catalyst and the reaction conditions was found to be crucial to achieve high levels of enantioselectivity for a variety of indoline products containing both tri- and tetrasubstituted stereocenters.

Graphical abstract: Palladium(0)-catalyzed asymmetric C(sp3)–H arylation using a chiral binol-derived phosphate and an achiral ligand

Supplementary files

Article information

Article type
Edge Article
Submitted
07 Sep 2016
Accepted
08 Oct 2016
First published
11 Oct 2016
This article is Open Access

All publication charges for this article have been paid for by the Royal Society of Chemistry
Creative Commons BY-NC license

Chem. Sci., 2017,8, 1344-1349

Palladium(0)-catalyzed asymmetric C(sp3)–H arylation using a chiral binol-derived phosphate and an achiral ligand

L. Yang, R. Melot, M. Neuburger and O. Baudoin, Chem. Sci., 2017, 8, 1344 DOI: 10.1039/C6SC04006C

This article is licensed under a Creative Commons Attribution-NonCommercial 3.0 Unported Licence. You can use material from this article in other publications, without requesting further permission from the RSC, provided that the correct acknowledgement is given and it is not used for commercial purposes.

To request permission to reproduce material from this article in a commercial publication, please go to the Copyright Clearance Center request page.

If you are an author contributing to an RSC publication, you do not need to request permission provided correct acknowledgement is given.

If you are the author of this article, you do not need to request permission to reproduce figures and diagrams provided correct acknowledgement is given. If you want to reproduce the whole article in a third-party commercial publication (excluding your thesis/dissertation for which permission is not required) please go to the Copyright Clearance Center request page.

Read more about how to correctly acknowledge RSC content.

Social activity

Spotlight

Advertisements