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Issue 34, 2017, Issue in Progress
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Construction of the oxaphenalene skeletons of mansonone F derivatives through C–H bond functionalization and their evaluation for anti-proliferative activities

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Abstract

Novel mansonone F derivatives were conveniently synthesized via a key step of Ru(II)-catalyzed C–H functionalization to rapidly construct oxaphenalene skeletons. This synthetic procedure is sufficiently robust and flexible to offer both the generation of diverse mansonone F analogs and the scale-up synthesis of selected compounds. The structural formulas of all products were confirmed and characterized using spectral data. Most of the derivatives exhibited significant cytotoxicity against four tested human tumor cell lines in vitro.

Graphical abstract: Construction of the oxaphenalene skeletons of mansonone F derivatives through C–H bond functionalization and their evaluation for anti-proliferative activities

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Publication details

The article was received on 03 Jan 2017, accepted on 03 Apr 2017 and first published on 12 Apr 2017


Article type: Paper
DOI: 10.1039/C7RA00090A
Citation: RSC Adv., 2017,7, 20919-20928
  • Open access: Creative Commons BY license
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    Construction of the oxaphenalene skeletons of mansonone F derivatives through C–H bond functionalization and their evaluation for anti-proliferative activities

    H. Xie, D. Zhou, Y. Mai, L. Huo, P. Yao, S. Huang, H. Wang, Z. Huang and L. Gu, RSC Adv., 2017, 7, 20919
    DOI: 10.1039/C7RA00090A

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