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Issue 83, 2017
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Fischer indole synthesis applied to the total synthesis of natural products

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Abstract

One of the oldest and most useful reactions in organic chemistry is the Fischer indole synthesis (FIS). It is known to have a wide variety of applications including the synthesis of indole rings, often present as the framework in the total synthesis of natural products, particularly those found in the realm of alkaloids, which comprise a ring system known as an indole alkaloid. In this review, we are trying to emphasize the applications of FIS as an old reaction, which is currently applied to the total synthesis of biologically active natural products and some other complex targets.

Graphical abstract: Fischer indole synthesis applied to the total synthesis of natural products

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Article information


Submitted
27 Sep 2017
Accepted
03 Nov 2017
First published
15 Nov 2017

This article is Open Access

RSC Adv., 2017,7, 52852-52887
Article type
Review Article

Fischer indole synthesis applied to the total synthesis of natural products

Majid M. Heravi, S. Rohani, V. Zadsirjan and N. Zahedi, RSC Adv., 2017, 7, 52852 DOI: 10.1039/C7RA10716A

This article is licensed under a Creative Commons Attribution 3.0 Unported Licence. You can use material from this article in other publications without requesting further permissions from the RSC, provided that the correct acknowledgement is given.

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