Issue 74, 2017, Issue in Progress

Regioselective C–H chlorination: towards the sequential difunctionalization of phenol derivatives and late-stage chlorination of bioactive compounds

Abstract

We have developed a protocol for the auxillary directed C–H chlorination of phenol derivatives using catalytic amounts of palladium acetate that is amenable to the late-stage chlorination of diflufenican and estrone. The 2-pyridine group allows for a highly efficient palladium-catalyzed chlorination and sequential ortho C–H functionalization reaction of phenol derivatives to produce a variety of symmetrical and unsymmetrical 2,4,6-trisubstituted phenols.

Graphical abstract: Regioselective C–H chlorination: towards the sequential difunctionalization of phenol derivatives and late-stage chlorination of bioactive compounds

Supplementary files

Article information

Article type
Paper
Submitted
06 Sep 2017
Accepted
25 Sep 2017
First published
03 Oct 2017
This article is Open Access
Creative Commons BY license

RSC Adv., 2017,7, 46636-46643

Regioselective C–H chlorination: towards the sequential difunctionalization of phenol derivatives and late-stage chlorination of bioactive compounds

C. Gao, H. Li, M. Liu, J. Ding, X. Huang, H. Wu, W. Gao and G. Wu, RSC Adv., 2017, 7, 46636 DOI: 10.1039/C7RA09939H

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