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Issue 72, 2017, Issue in Progress
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Far-red fluorescent carbon nano-onions as a biocompatible platform for cellular imaging

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Abstract

A new generation of fluorescent carbon nano-onions with enhanced solubility in biological media and bright photoluminescence is reported. The nano-onions functionalized with a water soluble boron dipyrromethene dye emit in the far red spectrum with a high quantum yield (ΦF) and are suitable for high resolution imaging. The nanoparticles are characterized by a variety of different analytical techniques such as thermogravimetric analysis, dynamic light scattering, zeta potential, electron microscopy, Raman, X-ray photoelectron and fluorescence spectroscopies. They are easily internalized by human breast cancer cells (MCF-7) without any significant toxic effects. Moreover, confocal imaging studies show they exhibit a high fluorescence intensity and are localized in the lysosomes at a very low concentration. Our findings confirm the excellent potentialities of these functionalized carbon nanomaterials as biocompatible platform for high resolution biological imaging.

Graphical abstract: Far-red fluorescent carbon nano-onions as a biocompatible platform for cellular imaging

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Publication details

The article was received on 25 Aug 2017, accepted on 15 Sep 2017 and first published on 25 Sep 2017


Article type: Paper
DOI: 10.1039/C7RA09442F
Citation: RSC Adv., 2017,7, 45676-45681
  • Open access: Creative Commons BY-NC license
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    Far-red fluorescent carbon nano-onions as a biocompatible platform for cellular imaging

    S. Lettieri, A. Camisasca, M. d'Amora, A. Diaspro, T. Uchida, Y. Nakajima, K. Yanagisawa, T. Maekawa and S. Giordani, RSC Adv., 2017, 7, 45676
    DOI: 10.1039/C7RA09442F

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