Issue 72, 2017, Issue in Progress
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RSC Advances

Pseudo three-component approach to coumarin-annulated azepines: synthesis of coumarin[3,4-b]azepines†

Kiran B. Manjappa,a   Yu-Ting Peng,a   Teau-Jiuan Lioub  and  Ding-Yah Yang ORCID logo *a  

* Corresponding authors

a Department of Chemistry, Tunghai University, No. 1727, Sec. 4, Taiwan Boulevard, Xitun District, Taichung 40704, Taiwan
E-mail: yang@thu.edu.tw

b Department of Applied English, Chaoyang University of Technology, No. 168, Jifeng E. Rd., Wufeng District, Taichung 41349, Taiwan

Abstract

A series of coumarin-annulated azepines were synthesized via acid-catalyzed condensation of 3-amino-4-hydroxycoumarin with two equivalents of substituted acetophenones in toluene with moderate to good yields. A plausible mechanism for this pseudo three-component reaction was proposed.

Graphical abstract: Pseudo three-component approach to coumarin-annulated azepines: synthesis of coumarin[3,4-b]azepines

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Article information

DOI
https://doi.org/10.1039/C7RA09289J
Article type
Paper
Submitted
22 Aug 2017
Accepted
15 Sep 2017
First published
22 Sep 2017
This article is Open Access
Creative Commons BY-NC license

RSC Adv., 2017,7, 45269-45273

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Pseudo three-component approach to coumarin-annulated azepines: synthesis of coumarin[3,4-b]azepines

K. B. Manjappa, Y. Peng, T. Liou and D. Yang, RSC Adv., 2017, 7, 45269 DOI: 10.1039/C7RA09289J

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