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Issue 71, 2017, Issue in Progress
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Biomimetic hollow mesoporous hydroxyapatite microsphere with controlled morphology, entrapment efficiency and degradability for cancer therapy

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Abstract

Hollow hydroxyapatite (HAp) microspheres bearing hierarchical structures have been one of the most popular carriers for drug delivery. However, it's been challenging to find an approach that can simultaneously control the morphology, degradability and drug loading/releasing properties of the microsphere. In this study, hollow mesoporous microspheres composed of nano-sized HAp crystals were hydrothermally synthesized from hollow CaCO3 precursors prepared via sodium dodecyl sulfate (SDS)-assisted precipitation. The particle size, hollow structure and wall thickness of the fabricated hollow mesoporous carbonated HAp microsphere (CHAM) could be facilely regulated by tailoring the concentration of SDS in the reaction. The achieved carbonate-containing CHAMs were demonstrated to be suitable for drug delivery through either surface attachment or intracellular engulfment without causing cytotoxicity. In addition, their distinguished biodegradability and sustained drug release properties in a pH-dependent manner might allow them to be used in cancer treatment by targeting the acidic microenvironment in a solid tumor. Moreover, the CHAM prepared using SDS at its critical micelle concentration (CMC) was suggested to be optimal for anti-cancer therapy due to its highest entrapment efficiency of cis-diammineplatinum(II) dichloride (CDDP) and the strongest killing effect on human squamous cell carcinoma in vitro.

Graphical abstract: Biomimetic hollow mesoporous hydroxyapatite microsphere with controlled morphology, entrapment efficiency and degradability for cancer therapy

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Publication details

The article was received on 20 Aug 2017, accepted on 13 Sep 2017 and first published on 19 Sep 2017


Article type: Paper
DOI: 10.1039/C7RA09204K
Citation: RSC Adv., 2017,7, 44788-44798
  • Open access: Creative Commons BY-NC license
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    Biomimetic hollow mesoporous hydroxyapatite microsphere with controlled morphology, entrapment efficiency and degradability for cancer therapy

    W. Qiao, X. Lan, J. K. H. Tsoi, Z. Chen, R. Y. X. Su, Kelvin W. K. Yeung and J. P. Matinlinna, RSC Adv., 2017, 7, 44788
    DOI: 10.1039/C7RA09204K

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