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Issue 83, 2017, Issue in Progress
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Value of mir-247 in warning of graphene oxide toxicity in nematode Caenorhabditis elegans

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Abstract

Graphene oxide (GO) induces some dysregulated microRNAs (miRNAs), such as mir-247, in Caenorhabditis elegans. We here further investigated the role and value of mir-247 in detecting GO toxicity in nematodes after prolonged exposure. In nematodes, mir-247 acted in neurons to regulate GO toxicity, and neuronal overexpression of mir-247 induced a susceptibility to GO toxicity. We detected the significant increase in mir-247 in wild-type nematodes exposed to GO at concentrations of more than 10 μg L−1. Moreover, we found the GO toxicity in a transgenic strain overexpressing neuronal mir-247 after exposure to GO at concentrations of more than 10 μg L−1. Therefore, our results imply the important potential of mir-247 in warning of the formation of GO toxicity in the range of μg L−1 in nematodes.

Graphical abstract: Value of mir-247 in warning of graphene oxide toxicity in nematode Caenorhabditis elegans

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Publication details

The article was received on 17 Aug 2017, accepted on 03 Nov 2017 and first published on 14 Nov 2017


Article type: Paper
DOI: 10.1039/C7RA09100A
Citation: RSC Adv., 2017,7, 52694-52701
  • Open access: Creative Commons BY license
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    Value of mir-247 in warning of graphene oxide toxicity in nematode Caenorhabditis elegans

    G. Xiao, L. Zhi, X. Ding, Q. Rui and D. Wang, RSC Adv., 2017, 7, 52694
    DOI: 10.1039/C7RA09100A

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