Issue 72, 2017

Flow synthesis of secondary amines over Ag/Al2O3 catalyst by one-pot reductive amination of aldehydes with nitroarenes

Abstract

An alumina-supported silver catalyst was investigated in the one-pot reductive amination of aldehydes with nitroarenes in a continuous flow reactor using molecular hydrogen as a reducing agent. A series of secondary amines containing alkyl, OH, OCH3, Cl, Br and C[double bond, length as m-dash]C groups was synthesized in good to excellent yields. The yield of the secondary amine depends on the rate of formation of an intermediate imine. It was shown that the accumulation of carbonaceous deposits on the catalyst is the main reason of catalyst deactivation. The spent catalyst can be easily regenerated and reused without losing catalytic activity.

Graphical abstract: Flow synthesis of secondary amines over Ag/Al2O3 catalyst by one-pot reductive amination of aldehydes with nitroarenes

Supplementary files

Article information

Article type
Paper
Submitted
14 Aug 2017
Accepted
20 Sep 2017
First published
26 Sep 2017
This article is Open Access
Creative Commons BY license

RSC Adv., 2017,7, 45856-45861

Flow synthesis of secondary amines over Ag/Al2O3 catalyst by one-pot reductive amination of aldehydes with nitroarenes

E. A. Artiukha, Alexey L. Nuzhdin, G. A. Bukhtiyarova and V. I. Bukhtiyarov, RSC Adv., 2017, 7, 45856 DOI: 10.1039/C7RA08986D

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