Issue 72, 2017

Recent advances in synthetic facets of immensely reactive azetidines

Abstract

The synthetic chemistry of azetidine constitutes an important yet undeveloped research area, in spite of their ubiquity in natural products and importance in medicinal chemistry. Their aptness as amino acid surrogates along with their potential in peptidomimetic and nucleic acid chemistry is considered remarkable. Azetidines also possess important prospects in other settings such as catalytic processes including Henry, Suzuki, Sonogashira and Michael additions. They also represent an important class of strained compounds making them excellent candidates for ring-opening and expansion reactions. With this in mind, the present review article addresses the recent developments in synthetic strategies towards functionalized azetidines along with their versatility as heterocyclic synthons.

Graphical abstract: Recent advances in synthetic facets of immensely reactive azetidines

Article information

Article type
Review Article
Submitted
11 Aug 2017
Accepted
20 Sep 2017
First published
27 Sep 2017
This article is Open Access
Creative Commons BY license

RSC Adv., 2017,7, 45763-45783

Recent advances in synthetic facets of immensely reactive azetidines

V. Mehra, I. Lumb, A. Anand and V. Kumar, RSC Adv., 2017, 7, 45763 DOI: 10.1039/C7RA08884A

This article is licensed under a Creative Commons Attribution 3.0 Unported Licence. You can use material from this article in other publications without requesting further permissions from the RSC, provided that the correct acknowledgement is given.

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