Issue 80, 2017
From the journal:

RSC Advances

Isolation, structure elucidation, and KDD study of (−)-Celosine, a new skeleton with potent anti-atherosclerosis activity†

Zhenliang Sun,ac   Zhiliang Lv, ORCID logo *b   Bin Hu,d   Jifa Zhang,a   Peng Du,b   Man Wang,a   Linlin Xiaoa  and  Peiming Yang*c  

* Corresponding authors

a 6th People's Hospital South Campus, Shanghai Jiao Tong University, Shanghai, China

b Zhangjiang Branch Institute of Chinese State Institute of Pharmaceutical Industry, Shanghai, China

c State Key Laboratory of New Drug and Pharmaceutical Process, Shanghai Institute of Pharmaceutical Industry, China State Institute of Pharmaceutical Industry, Shanghai, China

d Instrumental Analysis Center, Chinese State Institute of Pharmaceutical Industry, Shanghai, China

Abstract

Natural (−)-Celosine was isolated as a novel endocyclicditerpene with an unprecedented skeleton from Celosia cristata L. Its structure was established by comprehensive 1D and 2D NMR spectroscopic analysis in combination with single-crystal X-ray crystallographic diffraction of synthesized (+)-Celosine. (−)-Celosine was expected to have an anti-atherosclerotic activity in vivo, and myeloperoxidase (MPO) expression may be the mechanism underlying this anti-atherosclerotic activity.

Graphical abstract: Isolation, structure elucidation, and KDD study of (−)-Celosine, a new skeleton with potent anti-atherosclerosis activity

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Article information

DOI
https://doi.org/10.1039/C7RA08683K
Article type
Paper
Submitted
06 Aug 2017
Accepted
25 Oct 2017
First published
01 Nov 2017
This article is Open Access
Creative Commons BY-NC license

RSC Adv., 2017,7, 50875-50879

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Isolation, structure elucidation, and KDD study of (−)-Celosine, a new skeleton with potent anti-atherosclerosis activity

Z. Sun, Z. Lv, B. Hu, J. Zhang, P. Du, M. Wang, L. Xiao and P. Yang, RSC Adv., 2017, 7, 50875 DOI: 10.1039/C7RA08683K

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