Issue 70, 2017

Copper-catalyzed selective C–N bond formation with 2-amino, 2-hydroxy and 2-bromo-5-halopyridine

Abstract

A copper-catalyzed 1,2-diol amination at the electron-rich C-5 position of unprotected 2-amino/2-hydroxy-5-halopyridine provided excellent yields. Selective amination preferably at C-5 in 2-bromo-5-iodopyridine was achieved under the same conditions. The selective, generally mild and economical coupling reaction at C-5 position described herein could be achieved with amines, heterocycles and amides.

Graphical abstract: Copper-catalyzed selective C–N bond formation with 2-amino, 2-hydroxy and 2-bromo-5-halopyridine

Supplementary files

Article information

Article type
Paper
Submitted
01 Aug 2017
Accepted
31 Aug 2017
First published
15 Sep 2017
This article is Open Access
Creative Commons BY-NC license

RSC Adv., 2017,7, 44366-44370

Copper-catalyzed selective C–N bond formation with 2-amino, 2-hydroxy and 2-bromo-5-halopyridine

S. Roy, B. Paul, A. Mukherjee, B. Kundu and A. Talukdar, RSC Adv., 2017, 7, 44366 DOI: 10.1039/C7RA08482J

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