Jump to main content
Jump to site search

Issue 79, 2017, Issue in Progress
Previous Article Next Article

Collagen modified with epoxidized safrole for improving antibacterial activity

Author affiliations

Abstract

An epoxidized safrole, 5-(oxiran-2-ylmethyl)-benzo[d][1,3]dioxole (OYBD), was synthesized and employed to modify collagen for improving its antibacterial activity. The interaction between collagen and OYBD, and the structure/properties of the modified collagen were investigated in detail. The results indicated that the OYBD-modified collagen showed a higher de-nature temperature (Td, 90.2 °C), improved hydrophobic properties (contact angle from 84.2° to 89.1°) and enhanced tensile strength (6.2–11.0%) without destroying its triple helix structure. From observation of scanning electron microscopy (SEM), a higher density of intertwining morphology and a more stable network structure were observed, which was consistent with improved tensile strength and reduced breaking extension stress. The antibacterial test and LIVE/DEAD Baclight bacterial viability assay illustrated that the modified collagen exhibited excellent antibacterial activity to both Gram-negative and Gram-positive bacteria. Furthermore, the OYBD-modified collagen still exhibited cytocompatibility, supporting human fibroblast proliferation, which holds a great potential for developing antibacterial collagen-based biomaterials.

Graphical abstract: Collagen modified with epoxidized safrole for improving antibacterial activity

Back to tab navigation

Publication details

The article was received on 27 Jul 2017, accepted on 21 Oct 2017 and first published on 27 Oct 2017


Article type: Paper
DOI: 10.1039/C7RA08319J
RSC Adv., 2017,7, 50300-50306
  • Open access: Creative Commons BY-NC license
  •   Request permissions

    Collagen modified with epoxidized safrole for improving antibacterial activity

    Z. Xu, J. Chang, P. Zhang, X. Guan, Y. Chen and H. Fan, RSC Adv., 2017, 7, 50300
    DOI: 10.1039/C7RA08319J

    This article is licensed under a Creative Commons Attribution-NonCommercial 3.0 Unported Licence. Material from this article can be used in other publications provided that the correct acknowledgement is given with the reproduced material and it is not used for commercial purposes.

    Reproduced material should be attributed as follows:

    • For reproduction of material from NJC:
      [Original citation] - Published by The Royal Society of Chemistry (RSC) on behalf of the Centre National de la Recherche Scientifique (CNRS) and the RSC.
    • For reproduction of material from PCCP:
      [Original citation] - Published by the PCCP Owner Societies.
    • For reproduction of material from PPS:
      [Original citation] - Published by The Royal Society of Chemistry (RSC) on behalf of the European Society for Photobiology, the European Photochemistry Association, and RSC.
    • For reproduction of material from all other RSC journals:
      [Original citation] - Published by The Royal Society of Chemistry.

    Information about reproducing material from RSC articles with different licences is available on our Permission Requests page.

Search articles by author

Spotlight

Advertisements