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Issue 72, 2017, Issue in Progress
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1H NMR metabolomic signatures related to giant cell tumor of the bone

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Abstract

Giant cell tumor of the bone (GCTB) is an osteolytic neoplasm of uncertain biological behavior that affects the epiphyseal ends of long bones in young adults. This study describes for the first time the 1H NMR untargeted metabolic profiling of tissues from GCTB, which is clearly different from tissue controls. Applying univariate and multivariate analysis, fourteen differential metabolites were determinate and the major disturbed metabolic pathways included glycero-phospholipid metabolism and amino acid biosynthesis. These metabolic differences contribute to understand the molecular basis of GCTB and represent potential markers with future clinical applications.

Graphical abstract: 1H NMR metabolomic signatures related to giant cell tumor of the bone

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Supplementary files

Article information


Submitted
28 Jun 2017
Accepted
16 Sep 2017
First published
22 Sep 2017

This article is Open Access

RSC Adv., 2017,7, 45385-45392
Article type
Paper

1 H NMR metabolomic signatures related to giant cell tumor of the bone

F. J. Martínez-López, A. E. Bañuelos-Hernández, E. Becerra-Martínez, E. Santini-Araujo, R. A. Amaya-Zepeda, E. Pérez-Hernández and N. Pérez-Hernández, RSC Adv., 2017, 7, 45385
DOI: 10.1039/C7RA07138H

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