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Issue 63, 2017
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Sumalactones A–D, four new curvularin-type macrolides from a marine deep sea fungus Penicillium Sumatrense

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Abstract

Sumalactones A–D (1–4), four new curvularin-type macrolides, together with two known analogues, curvularin (5) and dehydrocurvularin (6), were isolated from Penicillium Sumatrense, a marine fungus isolated from deep-sea sediments. Sumalactones C (3) and D (4) are unprecedented curvularin-type macrolides bearing a rare 11-membered macrolide skeleton. Their structures were elucidated on the basis of intensive spectroscopic analysis. The absolute configurations of compounds 1–4 were determined by CD spectra and modified Mosher's method. Compound 6 showed significant inhibition activity towards LPS-induced nitric oxide production in RAW 264.7 macrophages with IC50 value of 0.91 μM.

Graphical abstract: Sumalactones A–D, four new curvularin-type macrolides from a marine deep sea fungus Penicillium Sumatrense

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Supplementary files

Article information


Submitted
21 Jun 2017
Accepted
24 Jul 2017
First published
16 Aug 2017

This article is Open Access

RSC Adv., 2017,7, 40015-40019
Article type
Paper

Sumalactones A–D, four new curvularin-type macrolides from a marine deep sea fungus Penicillium Sumatrense

Y. Wu, Z. Zhang, Y. Zhong, J. Huang, X. Li, J. Jiang, Y. Deng, L. Zhang and F. He, RSC Adv., 2017, 7, 40015
DOI: 10.1039/C7RA06933B

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