Design of a multifunctional vanadium pentoxide/polymer biocomposite for implant-coating applications

Abstract

In this study we designed a multifunctional implant coating by exploiting the properties of vanadium pentoxide (V₂O₅), i.e., the antibacterial activity via myeloperoxidase-like catalytic activity and the bioactivity of low concentrations of vanadate ions (dissolved form of V₂O₅) via the insulin-mimicking effect. To achieve this, the dissolution control of the V₂O₅ and the sustained release of the vanadate ions had to be achieved by processing the appropriate carrier system for the V₂O₅. Thus, we evaluated the ability of different polymeric carriers and the V₂O₅ particle morphology to modulate in vitro the stability of the prepared V₂O₅/polymeric coatings. For the control of the V₂O₅ dissolution it was crucial to control the diffusion of the particles from the polymeric matrix to the surrounding medium and to prevent extensive swelling of the polymer matrix. We highlighted the correlation between the strength of the interactions at the V₂O₅/polymer interface and the composite's stability under simulated physiological conditions. The optimum outcome was obtained for a nanowires-V₂O₅/PLGA composite coating that delivered vanadates sustainably, while at the same time preventing the colonization of S. epidermidis (NCIMB 8853) on its surface and ensuring the absence of any harmful effects on the red blood cells.