Direct C-2 acylation of indoles with toluene derivatives via Pd(II)-catalyzed C–H activation

Yaping Zhao; Upendra K. Sharma; Felix Schrӧder; Nandini Sharma; Gonghua Song; Erik V. Van der Eycken

doi:10.1039/C7RA06004A

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Direct C-2 acylation of indoles with toluene derivatives via Pd(II)-catalyzed C–H activation

Yaping Zhao, Upendra K. Sharma, Felix Schrӧder, Nandini Sharma, Gonghua Song and Erik V. Van der Eycken
RSC Adv., 2017,7, 32559-32563
DOI: 10.1039/C7RA06004A, Paper

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Abstract | Cited by

A simple and efficient Pd-catalyzed method for the C2-acylation of indoles is described. Less toxic, stable, and commercially available toluene derivatives were used as acyl sources, with tert-butylhydroperoxide (TBHP) as oxidant and pivalic acid as additive, providing moderate to good yields.

Graphical abstract: Direct C-2 acylation of indoles with toluene derivatives via Pd(ii)-catalyzed C–H activation

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