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Issue 48, 2017, Issue in Progress
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An antimalarial drug, tafenoquine, as a fluorescent receptor for ratiometric detection of hypochlorite

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Abstract

Tafenoquine (TQ), a fluorescent antimalarial drug, was used as a receptor for the fluorometric detection of hypochlorite (OCl). TQ itself exhibits a strong fluorescence at 476 nm, but OCl-selective cyclization of its pentan-1,4-diamine moiety creates a blue-shifted fluorescence at 361 nm. This ratiometric response facilitates rapid, selective, and sensitive detection of OCl in aqueous media with physiological pH. This response is also applicable to a simple test kit analysis and allows fluorometric OCl imaging in living cells.

Graphical abstract: An antimalarial drug, tafenoquine, as a fluorescent receptor for ratiometric detection of hypochlorite

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Supplementary files

Article information


Submitted
01 May 2017
Accepted
06 Jun 2017
First published
13 Jun 2017

This article is Open Access

RSC Adv., 2017,7, 30453-30458
Article type
Paper

An antimalarial drug, tafenoquine, as a fluorescent receptor for ratiometric detection of hypochlorite

A. K. Das, N. Hayashi, Y. Shiraishi and T. Hirai, RSC Adv., 2017, 7, 30453
DOI: 10.1039/C7RA04867J

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