Issue 60, 2017

(±)-Applanatumines B–D: novel dimeric meroterpenoids from Ganoderma applanatum as inhibitors of JAK3

Abstract

Applanatumines B–D (1–3), three pairs of dimeric meroterpenoid enantiomers featuring the presence of a 6-oxo-4,4a,5,5a,6,8,8a,8b-octahydrofuro[3′,4′:4,5]cyclopenta[1,2-b]pyran-3-carbaldehyde structure core, were isolated from the fruiting bodies of Ganoderma applanatum. Their structures and absolute configurations were assigned by using spectroscopic methods and ECD calculations. Biological evaluation found that all the compounds are JAK3 inhibitors. In addition, the enantiomers of 1 are active towards DDR1 with IC50 values of 8.2 ± 0.8 μM and 6.9 ± 0.8 μM. Finally, a plausible biogenic pathway for compounds 1–3 was proposed.

Graphical abstract: (±)-Applanatumines B–D: novel dimeric meroterpenoids from Ganoderma applanatum as inhibitors of JAK3

Supplementary files

Article information

Article type
Paper
Submitted
01 May 2017
Accepted
18 Jul 2017
First published
02 Aug 2017
This article is Open Access
Creative Commons BY-NC license

RSC Adv., 2017,7, 38037-38043

(±)-Applanatumines B–D: novel dimeric meroterpenoids from Ganoderma applanatum as inhibitors of JAK3

Q. Luo, Z. Wang, J. Luo, Z. Tu and Y. Cheng, RSC Adv., 2017, 7, 38037 DOI: 10.1039/C7RA04862A

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