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Issue 54, 2017
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1H and 19F NMR in drug stress testing: the case of voriconazole

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Abstract

Stress tests form an important part of drug development, and of subsequent accreditation. Commonly the change in chemical composition over time is determined using chromatographic methods that separate the mixture components, but when structural characterization of the degradation products is required, other methods are needed. Arguably the most powerful method for determining chemical structure information is NMR spectroscopy. Here we show that NMR alone, using a combination of simple 19F, 1H, and DOSY experiments, can characterise both structure and kinetics of an intact reaction mixture, without the need for any physical separation.

Graphical abstract: 1H and 19F NMR in drug stress testing: the case of voriconazole

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Supplementary files

Article information


Submitted
03 Apr 2017
Accepted
26 Jun 2017
First published
05 Jul 2017

This article is Open Access

RSC Adv., 2017,7, 34000-34004
Article type
Paper

1 H and 19F NMR in drug stress testing: the case of voriconazole

T. M. Barbosa, G. A. Morris, M. Nilsson, R. Rittner and C. F. Tormena, RSC Adv., 2017, 7, 34000
DOI: 10.1039/C7RA03822D

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