New alkaloids with unusual spermidine moieties from the seeds of Orychophragmus violaceus and their cytoprotective properties

Abstract

The seeds of the plant Orychophragmus violaceus yielded eight new spermidine alkaloids, termed orychophragmuspine A–H (1–8). Their structures were elucidated by extensive spectroscopic analysis and comparison with literature data. Compounds 1–8 are unusual natural alkaloids with spermidine moieties and were tested for cytoprotective properties. The results showed that all compounds displayed mild cytoprotective activities compared with the normal and model groups.