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Issue 30, 2017, Issue in Progress
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In situ formation of pH-responsive Prussian blue for photoacoustic imaging and photothermal therapy of cancer

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Abstract

Designing theranostic agents that are responsive to weakly acidic tumor microenvironments for optimized imaging and therapeutic effects is of great interest in nanomedicine. In the current study, we constructed a pH-triggered smart theranostic system based on pH-responsive Prussian blue, which shows good performance in the photoacoustic imaging (PAI)-guided photothermal therapy (PTT) of tumors. Precursors to Prussian blue, namely ferrous and ferricyanide ions, were separately encapsulated into pH-responsive hydrogels that only degraded under acidic conditions. In vitro results showed that the encapsulated ions were gradually released in acidic buffer, accompanied by hydrogel degradation. After the resultant hydrogel was mixed and intratumorally injected into tumor-bearing mice, the encapsulated ferrous ions and ferricyanide ions were successfully released in the acidic tumor environment, allowing the in situ formation of Prussian blue in the tumor area. This provided an efficient theranostic agent for PAI-guided PTT of cancer. Our research highlights the potential of Prussian blue-based theranostic agents for the precise diagnosis and treatment of cancer.

Graphical abstract: In situ formation of pH-responsive Prussian blue for photoacoustic imaging and photothermal therapy of cancer

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Publication details

The article was received on 15 Feb 2017, accepted on 09 Mar 2017 and first published on 27 Mar 2017


Article type: Paper
DOI: 10.1039/C7RA01879G
RSC Adv., 2017,7, 18270-18276
  • Open access: Creative Commons BY license
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    In situ formation of pH-responsive Prussian blue for photoacoustic imaging and photothermal therapy of cancer

    M. Cheng, W. Peng, P. Hua, Z. Chen, J. Sheng, J. Yang and Y. Wu, RSC Adv., 2017, 7, 18270
    DOI: 10.1039/C7RA01879G

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