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Issue 55, 2017
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Evaluation of the anti-inflammatory properties of telmesteine on inflammation-associated skin diseases

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Abstract

Telmesteine, a useful agent for respiratory tract disorders, has been reported to be a critical active ingredient in topical compositions for dermatitis. The present study was designed to elucidate the in vitro and in vivo anti-inflammatory properties of telmesteine. LPS-induced NO production in RAW264.7 cells was significantly decreased after telmesteine treatment. TPA-induced skin inflammation as assessed by skin edema and pro-inflammatory cytokines (IL-1β, IL-6, and TNF-α) was significantly decreased after telmesteine topical treatment. Further analysis results demonstrated that the anti-inflammation properties of telmesteine were associated with its ability to inhibit activation of nuclear factor kappa-κB (NF-κB) by blocking phosphoinositide 3-kinase/protein kinase B (PI3K/Akt)/IκB kinase (IKK) activities.

Graphical abstract: Evaluation of the anti-inflammatory properties of telmesteine on inflammation-associated skin diseases

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Publication details

The article was received on 25 Jan 2017, accepted on 22 Jun 2017 and first published on 11 Jul 2017


Article type: Paper
DOI: 10.1039/C7RA01111C
Citation: RSC Adv., 2017,7, 34699-34704
  • Open access: Creative Commons BY license
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    Evaluation of the anti-inflammatory properties of telmesteine on inflammation-associated skin diseases

    X. Xu, D. Huang, W. Liu, Z. Sheng, K. Liang, D. Li, D. Zhao, Y. Ma, K. Zhang, T. Hayat, N. S. Alharbi and W. Li, RSC Adv., 2017, 7, 34699
    DOI: 10.1039/C7RA01111C

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