Efficient one-pot synthesis of 3,4-dihydropyrimidin-2(1H)-ones catalyzed by a new heterogeneous catalyst based on Co-functionalized Na+-montmorillonite

Abstract

In the present study, we report a simple, facile and efficient solvent-free protocol for the synthesis of 3,4-dihydropyrimidin-2(1H)-ones by the three component condensation of aldehyde, ethyl acetoacetate and urea through using Co@imine-Na⁺-MMT as a new, environmentally friendly and reusable heterogeneous catalyst. The structure of the synthesized catalyst was characterized by various techniques, including IR, SEM, TGA, EDX, AAs, DR-UV-vis and XRD analyses. Green reaction conditions, high quantitative yields and the easy isolation of products, easy separation and recovery of the catalyst and short reaction times are some of the advantages of our procedure.