Oxidative cross-coupling reaction by scandium catalysis for synthesis of α-alkyl α-amino acid ester derivatives

Abstract

A novel oxidative cross-coupling reaction between N-arylglycine esters and alkyl boronic acid esters for synthesis of α-alkyl α-amino acid esters in the presence of scandium catalysis using silver salt as an oxidant has been developed. The mild reaction has an excellent functional group tolerance and gives the desired α-alkyl α-amino acid esters in a moderate to excellent yield.