A dansyl-based fluorescent probe for the highly selective detection of cysteine based on a d-PeT switching mechanism

Yudong Xiao; Yujin Guo; Ruili Dang; Xin Yan; Pengfei Xu; Pei Jiang

doi:10.1039/C7RA00212B

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A dansyl-based fluorescent probe for the highly selective detection of cysteine based on a d-PeT switching mechanism†

Yudong Xiao,^b Yujin Guo,^a Ruili Dang,^a Xin Yan,^c Pengfei Xu

*^a and Pei Jiang*^a

Author affiliations

* Corresponding authors

^a Institute of Clinical Pharmacy & Pharmacology, Jining First People's Hospital, Jining Medical University, Jining 272000, China
E-mail: jiangpeicsu@sina.com, pengfeixucsu@outlook.com

^b Department of Radiology, The Second Xiangya Hospital of Central South University, Changsha 410010, China

^c Research Center for Drug Discovery, School of Pharmaceutical Sciences, Sun Yat-sen University, 132 East Circle at University City, Guangzhou, China

Abstract

A novel fluorescent probe, DN-C, for detection of cysteine (Cys) based on a d-PeT switching mechanism is reported. In the presence of Cys, the probe exhibits a turn-on fluorescence signal and nearly 28-fold fluorescence intensity enhancement. The cellular imaging experiment indicated the DN-C possess desirable cell permeability for biological applications.

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Article information

DOI: https://doi.org/10.1039/C7RA00212B
Article type: Paper
Submitted: 06 Jan 2017
Accepted: 03 Apr 2017
First published: 12 Apr 2017
This article is Open Access

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RSC Adv., 2017,7, 21050-21053

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A dansyl-based fluorescent probe for the highly selective detection of cysteine based on a d-PeT switching mechanism

Y. Xiao, Y. Guo, R. Dang, X. Yan, P. Xu and P. Jiang, RSC Adv., 2017, 7, 21050 DOI: 10.1039/C7RA00212B

This article is licensed under a Creative Commons Attribution 3.0 Unported Licence. You can use material from this article in other publications without requesting further permissions from the RSC, provided that the correct acknowledgement is given.

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A dansyl-based fluorescent probe for the highly selective detection of cysteine based on a d-PeT switching mechanism†

Abstract

Supplementary files

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A dansyl-based fluorescent probe for the highly selective detection of cysteine based on a d-PeT switching mechanism

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