Highly efficient electrochemical recognition and quantification of amine enantiomers based on a guest-free homochiral MOF

Abstract

We facilely synthesized a novel guest-free homochiral metal–organic framework, (Cu₄L₄)_n [H₂L = N-(2-hydroxybenzyl)-L-leucine] in space group P1. The (Cu₄L₄)_n nanocrystals exhibit high electrochemical activity for rapidly discriminating chiral α-methylbenzylamine enantiomers and quantitatively determining the enantiomeric excess in the chiral amine mixture.