Issue 19, 2017, Issue in Progress

Efficient synthesis of novel N-substituted 2-carboxy-4-quinolones via lithium bis(trimethylsilyl)amide (LiHMDS)-induced in situ cyclocondensation reaction

Abstract

A different approach for the synthesis of N-substituted 2-carboxy-4-quinolones using direct reductive amination followed by LiHMDS-induced cyclocondensation has been developed. A range of analogues of the title compounds with broad substrate scope were obtained in moderate yields and good regioselectivity.

Graphical abstract: Efficient synthesis of novel N-substituted 2-carboxy-4-quinolones via lithium bis(trimethylsilyl)amide (LiHMDS)-induced in situ cyclocondensation reaction

Supplementary files

Article information

Article type
Paper
Submitted
23 Dec 2016
Accepted
06 Feb 2017
First published
13 Feb 2017
This article is Open Access
Creative Commons BY license

RSC Adv., 2017,7, 11367-11372

Efficient synthesis of novel N-substituted 2-carboxy-4-quinolones via lithium bis(trimethylsilyl)amide (LiHMDS)-induced in situ cyclocondensation reaction

P. Hasan, B. Aneja, Mir M. Masood, Md. B. Ahmad, U. Yadava, C. G. Daniliuc and M. Abid, RSC Adv., 2017, 7, 11367 DOI: 10.1039/C6RA28631C

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