A zeolite modified carbon paste electrode based on copper exchanged clinoptilolite nanoparticles for voltammetric determination of metronidazole

Abstract

A simple and effective zeolite modified electrode (ZME) was constructed from Cu(II)-exchanged clinoptilolite nanoparticles (Cu(II)-CNP). The modifier was characterized by FTIR, BET, XRD and TEM techniques. The modified carbon paste electrode (Cu(II)-CNP/CPE) was used for the voltammetric determination of metronidazole (MNZ). The best voltammetric response was obtained by the electrode containing 20% of the modifier in NaCl 0.4 mol L⁻¹ at pH 6. The electrode showed a linear response in the concentration range of 2.0 × 10⁻⁸ to 1.6 × 10⁻⁶ mol L⁻¹ MNZ with a detection limit of 4.1 × 10⁻⁹ mol L⁻¹ from square wave voltammetry. The electrode showed good repeatability, reproducibility, and a long lifetime based on statistical tests. The electrode also has good selectivity and good applicability in the determination of MNZ in some pharmaceutical samples.