Issue 23, 2017, Issue in Progress
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RSC Advances

Highly efficient one-pot three-component Betti reaction in water using reverse zinc oxide micelles as a recoverable and reusable catalyst†

Jie Mou, ORCID logo ‡*ab   Gan Gao,‡ab   Chen Chen,‡ab   Jie Liu,ab   Jian Gao,ab   Yi Liuab  and  Dongsheng Pei*c  

* Corresponding authors

a School of Pharmacy, Xuzhou Medical University, Xuzhou 221006, China

b Jiangsu Key Laboratory of New Drug and Clinical Pharmacy, Xuzhou Medical University, Xuzhou 221006, China

c Department of Pathology, Xuzhou Medical University, Xuzhou 221006, China
E-mail: dspei@xzhmu.edu.cn

Abstract

An efficient synthesis of Betti bases via a one-pot three-component reaction of 2-naphthol, substituted aldehydes and anilines in aqueous media is reported. Through screening different catalysts, reverse zinc oxide nanomicelles show good activity and high selectivity. The catalyst retained activity after six cycles of reuse and were recoverable. The method has the advantages of atom economy, short reaction time, good yield, and easy work-up as well as being environmental friendly.

Graphical abstract: Highly efficient one-pot three-component Betti reaction in water using reverse zinc oxide micelles as a recoverable and reusable catalyst

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Article information

DOI
https://doi.org/10.1039/C6RA28599F
Article type
Paper
Submitted
23 Dec 2016
Accepted
17 Feb 2017
First published
01 Mar 2017
This article is Open Access
Creative Commons BY-NC license

RSC Adv., 2017,7, 13868-13875

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Highly efficient one-pot three-component Betti reaction in water using reverse zinc oxide micelles as a recoverable and reusable catalyst

J. Mou, G. Gao, C. Chen, J. Liu, J. Gao, Y. Liu and D. Pei, RSC Adv., 2017, 7, 13868 DOI: 10.1039/C6RA28599F

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