Two rare meroterpenoidal rotamers from Ganoderma applanatum

Abstract

Applanatumols Z3 (1) and Z4 (2), two novel natural product hybrids consisting of a meroterpenoid and a glycerol and three known compounds (3–5) were isolated from the fruiting bodies of the fungus Ganoderma applanatum. Their structures were elucidated by means of spectroscopic methods, ECD and ¹³C NMR calculations. It is of particular interest that 1 and 2 are rare separable conformers. Racemic 1 and 2 were further separated by chiral HPLC to afford their respective enantiomers, whose biological activities were evaluated against JAK3 and DDR1 kinases.