Issue 4, 2017, Issue in Progress

Electrochemical detection of serotonin based on a poly(bromocresol green) film and Fe3O4 nanoparticles in a chitosan matrix

Abstract

A composite film containing poly(bromocresol green), magnetic nanoparticles and multiwalled carbon nanotubes was fabricated for the sensitive determination of serotonin. The poly(bromocresol green) was prepared by electropolymerization on a glassy carbon electrode surface, then the multiwalled carbon nanotubes and magnetic nanoparticles in a chitosan matrix were dropped onto the surface of the poly(bromocresol green) film. The modified electrode displayed an enhanced differential pulse voltammetric response to serotonin in the presence of dopamine. Its peak current (at an oxidation voltage of 0.36 V vs. Ag/AgCl) increased linearly in the serotonin concentration range 0.5–100 μM with a detection limit of 80 nM (at an S/N of 3). The sensor was highly sensitive and stable. It was applied to the direct determination of serotonin spiked into human serum samples. These results show that the nanocomposite films are good modifying materials for use in the fabrication of electrochemical sensors.

Graphical abstract: Electrochemical detection of serotonin based on a poly(bromocresol green) film and Fe3O4 nanoparticles in a chitosan matrix

Supplementary files

Article information

Article type
Paper
Submitted
21 Oct 2016
Accepted
29 Nov 2016
First published
12 Jan 2017
This article is Open Access
Creative Commons BY license

RSC Adv., 2017,7, 1847-1851

Electrochemical detection of serotonin based on a poly(bromocresol green) film and Fe3O4 nanoparticles in a chitosan matrix

G. Ran, X. Chen and Y. Xia, RSC Adv., 2017, 7, 1847 DOI: 10.1039/C6RA25639B

This article is licensed under a Creative Commons Attribution 3.0 Unported Licence. You can use material from this article in other publications without requesting further permissions from the RSC, provided that the correct acknowledgement is given.

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