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Issue 4, 2017
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Facile one-pot synthesis of magnetic nitrogen-doped porous carbon for high-performance bilirubin removal from BSA-rich solution

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Abstract

The development of high-performance adsorbents for efficient removal of bilirubin from albumin-rich solution is still a considerable challenge. In this study, a magnetic nitrogen-doped porous carbon (m-NpC) was facilely synthesized through a simple one-pot route using the biomass chitosan and the iron salt Fe(NO3)3·9H2O as precursors, and NaCl as template agent, respectively. Intriguingly, the resulting m-NpC material showed a hierarchically micro–meso–macroporous structure, high surface area (289 m2 g−1), large pore volume (0.33 cm3 g−1), and good magnetic response. In particular, the basic site-rich surface of m-NpC obtained as a result of nitrogen doping could compete effectively with albumin for bilirubin binding. As such, the m-NpC was used as a magnetically separable bilirubin adsorbent and showed superior adsorption properties for bilirubin removal from a bovine serum albumin (BSA)-rich solution. Under optimized conditions, the maximum adsorption capacity of m-NpC was up to 72.4 mg g−1, which is significantly higher than the value achieved by magnetic non-nitrogen doped porous carbon (24.7 mg g−1), but also superior to those of many previously reported adsorbents for BSA-boned bilirubin removal. Moreover, as evidenced by hemolysis assay, this material exhibited only a negligible hemolysis effect. These results suggest that the composite developed in this work can be used as a promising adsorbent in blood purification application to mitigate the risk of excess bilirubin.

Graphical abstract: Facile one-pot synthesis of magnetic nitrogen-doped porous carbon for high-performance bilirubin removal from BSA-rich solution

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Publication details

The article was received on 11 Oct 2016, accepted on 30 Nov 2016 and first published on 12 Jan 2017


Article type: Paper
DOI: 10.1039/C6RA25027K
RSC Adv., 2017,7, 2081-2091
  • Open access: Creative Commons BY-NC license
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    Facile one-pot synthesis of magnetic nitrogen-doped porous carbon for high-performance bilirubin removal from BSA-rich solution

    C. Ma, Q. Gao, J. Zhou, Q. Chen, B. Han, K. Xia and C. Zhou, RSC Adv., 2017, 7, 2081
    DOI: 10.1039/C6RA25027K

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