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Issue 22, 2017, Issue in Progress
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Synthesis of quaternary phosphonium N-chloramine biocides for antimicrobial applications

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Abstract

The recently developed quaternary ammonium (QA) N-chloramine has been proved to be a promising “composite” biocide with drastically boosted antibacterial efficacy afforded by the QA moiety. In this work, a series of quaternary phosphonium (QP) N-chloramine biocides, covalently combining an N-chloramine moiety and a QP moiety via varied aliphatic methylene units, were synthesized by means of multi-step chemical reactions. Preliminary antibacterial tests against both Escherichia coli (E. coli) and Staphylococcus aureus (S. aureus) showed that the synthetic QP N-chloramine exhibited distinctively higher biocidal efficacy than the QA counterpart. Furthermore, bactericidal tests also indicated that QP N-chloramine with a linker of –(CH2)12– showed the highest biocidal efficacy, suggesting synergistic action between the N-chloramine moiety and QP moiety.

Graphical abstract: Synthesis of quaternary phosphonium N-chloramine biocides for antimicrobial applications

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Supplementary files

Article information


Submitted
10 Oct 2016
Accepted
21 Feb 2017
First published
27 Feb 2017

This article is Open Access

RSC Adv., 2017,7, 13244-13249
Article type
Paper

Synthesis of quaternary phosphonium N-chloramine biocides for antimicrobial applications

L. Li, H. Zhou, F. Gai, X. Chi, Y. Zhao, F. Zhang and Z. Zhao (Kent), RSC Adv., 2017, 7, 13244
DOI: 10.1039/C6RA24954J

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