Issue 12, 2017

A practical approach for the synthesis of oxindole and isatin derivatives by Pd-catalyzed intramolecular amination

Abstract

Oxindole/isatin-N-acetamide derivatives are a class of important pharmacologically active compounds. Herein, we report a practical protocol for the synthesis of such derivatives based on palladium-catalyzed intramolecular amination. Various functional groups are tolerated, and the corresponding products are obtained in moderate to good yields, highlighting the potential synthetic utility of this method.

Graphical abstract: A practical approach for the synthesis of oxindole and isatin derivatives by Pd-catalyzed intramolecular amination

Supplementary files

Article information

Article type
Research Article
Submitted
11 Aug 2017
Accepted
04 Sep 2017
First published
05 Sep 2017

Org. Chem. Front., 2017,4, 2408-2411

A practical approach for the synthesis of oxindole and isatin derivatives by Pd-catalyzed intramolecular amination

Y. Pang, M. Guan, R. Zeng and Y. Zhao, Org. Chem. Front., 2017, 4, 2408 DOI: 10.1039/C7QO00710H

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