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Issue 9, 2017
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meta-Selective C–H difluoromethylation of various arenes with a versatile ruthenium catalyst

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Abstract

A ruthenium-enabled meta-selective C–H difluoromethylation of arenes has been developed. Various arenes bearing pyridyl, pyrazolyl, imidazolyl, or pyrimidyl directing groups, or removable oxazoline directing groups, were tolerated in this meta-selective C–H difluoromethylation, affording the difluoromethylated products in moderate to good yields. The difluoromethyl group could be selectively installed into several drug molecules and bioactive compounds in one step, highlighting the synthetic utility and importance of this new method.

Graphical abstract: meta-Selective C–H difluoromethylation of various arenes with a versatile ruthenium catalyst

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Supplementary files

Article information


Submitted
07 Jun 2017
Accepted
17 Jun 2017
First published
19 Jun 2017

Org. Chem. Front., 2017,4, 1867-1871
Article type
Research Article

meta-Selective C–H difluoromethylation of various arenes with a versatile ruthenium catalyst

C. C. Yuan, X. L. Chen, J. Y. Zhang and Y. S. Zhao, Org. Chem. Front., 2017, 4, 1867
DOI: 10.1039/C7QO00449D

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