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Issue 7, 2017
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Enantioselective synthesis of a cyclobutane analogue of Milnacipran

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Abstract

The asymmetric synthesis of a cyclobutane analogue of the antidepressant drug Milnacipran is reported. The optically active derivative incorporates a central cyclobutane ring in lieu of the cyclopropane unit classically found in Milnacipran. The two stereogenic centres borne by the cyclobutane were sequentially installed starting from phenylacetonitrile.

Graphical abstract: Enantioselective synthesis of a cyclobutane analogue of Milnacipran

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Article information


Submitted
20 Feb 2017
Accepted
23 Mar 2017
First published
23 Mar 2017

Org. Chem. Front., 2017,4, 1276-1280
Article type
Research Article

Enantioselective synthesis of a cyclobutane analogue of Milnacipran

D. Nguyen, E. Gravel, D. Buisson, M. Nicolas and E. Doris, Org. Chem. Front., 2017, 4, 1276
DOI: 10.1039/C7QO00140A

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