A concise and efficient synthesis of (S,R)-Bn-Yanphos on a gram scale has been developed. When (S,R)-Bn-Yanphos was employed in Rh-catalyzed asymmetric hydroformylation of vinyl heteroarenes and allyl-1H-indole, it exhibited excellent catalytic activity, affording chiral heteroaryl aldehydes in good yields with high regio- and enantioselectivities (up to 96% ee).
B. Wei, C. Chen, C. You, H. Lv and X. Zhang, Org. Chem. Front., 2017, 4, 288 DOI: 10.1039/C6QO00641H
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