Issue 47, 2017
From the journal:

Polymer Chemistry

A nanoparticle-preparation kit using ethylene glycol-based block copolymers with a common temperature-responsive block†

Yohei Kotsuchibashi, ORCID logo *ab   Chun Man Lee,c   Iren Constantinescu,d   Lily E. Takeuchi,d   Sreeparna Vappala,d   Jayachandran N. Kizhakkedathu,de   Ravin Narain, ORCID logo f   Mitsuhiro Ebara ORCID logo bgh  and  Takao Aoyagii  

* Corresponding authors

a Department of Materials and Life Science, Shizuoka Institute of Science and Technology, 2200-2 Toyosawa, Fukuroi, Shizuoka 437-8555, Japan
E-mail: Kotsuchibashi.yohei@sist.ac.jp
Fax: +81-538-45-0110
Tel: +81-538-45-0170

b International Center for Materials Nanoarchitectonics (WPI-MANA), National Institute for Materials Science (NIMS), 1-1 Namiki, Tsukuba, Ibaraki 305-0044, Japan

c Medical Center for Translational Research, Osaka University Hospital, 2-15 Yamadaoka, Suita, Osaka 565-0871, Japan

d Centre for Blood Research, Department of Pathology and Laboratory Medicine, University of British Columbia, 2350 Health Sciences Mall, Vancouver, BC, Canada

e Department of Chemistry, University of British Columbia, 2350 Health Sciences Mall, Vancouver, BC, Canada

f Department of Chemical and Materials Engineering, University of Alberta, Edmonton, Alberta, Canada

g Materials and Science Engineering, Graduate School of Pure and Applied Sciences, University of Tsukuba, 1-1-1 Tennodai, Tsukuba, Ibaraki 305-8577, Japan

h Graduate School of Industrial Science and Technology, Tokyo University of Science, 6-3-1 Niijuku, Katsushika, Tokyo 125-8585, Japan

i Department of Materials and Applied Chemistry, Nihon University, 1-8-14 Kanda Surugadai, Chiyoda-ku, Tokyo 101-8308, Japan

Abstract

A nanoparticle-preparation kit system for producing desired nanoparticles using ethylene glycol-based block copolymers with a common temperature-responsive block was developed. The injected nanoparticles were found to accumulate in the tumor tissue and showed high blood biocompatibility.

Graphical abstract: A nanoparticle-preparation kit using ethylene glycol-based block copolymers with a common temperature-responsive block

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Article information

DOI
https://doi.org/10.1039/C7PY01541K
Article type
Communication
Submitted
08 Sep 2017
Accepted
08 Nov 2017
First published
22 Nov 2017

Polym. Chem., 2017,8, 7311-7315

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A nanoparticle-preparation kit using ethylene glycol-based block copolymers with a common temperature-responsive block

Y. Kotsuchibashi, C. M. Lee, I. Constantinescu, L. E. Takeuchi, S. Vappala, J. N. Kizhakkedathu, R. Narain, M. Ebara and T. Aoyagi, Polym. Chem., 2017, 8, 7311 DOI: 10.1039/C7PY01541K

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